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Best Hospitals for Peripheral Neuropathy: Top Treatment Centers Explored

Peripheral neuropathy is a type of damage to the nervous system that affects the peripheral nerves responsible for transmitting information between the brain, spinal cord, and the rest of the body.

Finding the right hospital for peripheral neuropathy treatment is crucial, as the condition's management can vary depending on the type of neuropathy, affected nerves' number and location, and personal health factors. This article highlights some of the best hospitals known for their specialized care and outstanding treatment of peripheral neuropathy.

Johns Hopkins Neurology's Peripheral Nerve Center is known for providing expert neurological and medical care for peripheral neuropathies. The center works in partnership with other institutions across Johns Hopkins to ensure that patients receive the best treatment approaches tailored to their specific needs.

Another reputable institution for peripheral neuropathy care is Mayo Clinic. With Mayo Clinic specialists treating over 16,400 people with peripheral neuropathy each year, they have a significant level of expertise in the field. Moreover, Mayo Clinic's campuses in Rochester, Minnesota, and Phoenix/Scottsdale, Arizona, rank among the best hospitals for neurology, neurosurgery, and cancer in the U.S. News & World Report rankings.

In addition to these renowned institutions, U.S. News also provides information on other hospitals in regions like New Jersey, known for treating challenging neurology and neurosurgery cases, including peripheral neuropathy.

The rankings and ratings provided by U.S. News can serve as a valuable resource for patients seeking the best care for their neuropathy conditions. The ultimate goal is to ensure that patients receive the most effective treatments, leading to improved quality of life and overall well-being.

Overview of Peripheral Neuropathy

Peripheral neuropathy is a type of damage to the nervous system, particularly to the peripheral nervous system. The peripheral nervous system is the network of nerves that transmits information from the brain and spinal cord (the central nervous system) to the rest of your body, facilitating a wide variety of functions such as movement and sensation.


Peripheral neuropathy can have various causes, including:

  • Diabetes mellitus
  • Autoimmune diseases such as Guillain-Barré syndrome and lupus
  • Traumatic injuries
  • Infections such as shingles and Lyme disease
  • Excessive alcohol consumption
  • Exposure to certain medications, like chemotherapy drugs or antiviral drugs
  • Vitamin deficiencies, particularly B vitamins


Symptoms of peripheral neuropathy can vary depending on the type of nerve affected (sensory, motor, or autonomic) and can include:

  • Numbness, tingling, and burning sensations in the hands and feet
  • Sharp, stabbing, freezing, or electric-like pain
  • Difficulty sensing heat, cold, or touch
  • Weakness and muscle atrophy (decrease in muscle size)
  • Muscle cramps, spasms, or tremors
  • Problems with balance, coordination, and walking
  • Digestive or urinary dysfunction in cases where autonomic nerves are affected

Symptoms often begin in the fingers and toes and may gradually spread towards the center of the body. In some cases, peripheral neuropathy may lead to additional complications such as foot ulcers, infections, and involvement of other systems and organs in the body.

When seeking treatment for peripheral neuropathy, it is important to consider hospitals that provide specialized care for this condition. Institutions such as Johns Hopkins Medicine, Mayo Clinic, and Cleveland Clinic offer comprehensive services, including expert neurological care, cutting-edge research, and multidisciplinary approaches to manage peripheral neuropathy effectively.

Diagnostic Evaluation

Clinical Examination

Your doctor will begin the diagnostic evaluation for peripheral neuropathy with a thorough clinical examination. They will gather information about your medical and family history, as well as the specifics of your symptoms, such as their duration, frequency, and intensity. During the physical examination, your doctor will assess your muscle strength, reflexes, and sensitivity to touch, vibration, and temperature.

Some causes of peripheral neuropathy, such as diabetes or hormone imbalances, may require further tests like blood tests to measure blood sugar, kidney function, and hormone levels. Identifying and managing the underlying cause of peripheral neuropathy can help improve symptoms and overall prognosis.


An electromyography (EMG) test can help your doctor determine the nature and severity of nerve involvement in peripheral neuropathy. An EMG measures the electrical activity of muscles at rest and during contraction, providing valuable information about nerve function and muscle response. A nerve conduction study (NCS) is often performed in conjunction with an EMG to provide a more comprehensive assessment of nerve function.

During an EMG, a needle electrode is inserted into the muscle, and the electrical activity is recorded. The needle may be moved to different muscles during the test to assess the various nerves involved. For the NCS, electrodes are placed on the skin, and small electrical shocks are applied to measure the speed of nerve conduction. These tests can help your doctor identify any nerve compression, radiculopathy, or peripheral nerve root lesions that may contribute to your peripheral neuropathy symptoms.

In addition to EMG and clinical examination, imaging studies such as MRI or CT scans may be used to rule out other potential causes of your symptoms, like spinal issues or tumors. Moreover, a nerve biopsy might be performed in some cases to obtain a more definitive diagnosis.

By thoroughly evaluating the clinical examination, electromyography, and additional tests as needed, your doctor can better understand your peripheral neuropathy and recommend the most appropriate treatment options for your specific case.

Best Hospitals for Peripheral Neuropathy

Mayo Clinic

Mayo Clinic is renowned for its expertise in treating peripheral neuropathy, with their specialists handling over 16,400 cases annually. Their facilities in Rochester, Minnesota, and Phoenix/Scottsdale, Arizona are ranked among the Best Hospitals for neurology, neurosurgery, and cancer by U.S. News & World Report. Mayo Clinic offers various treatments, such as medications like gabapentin and pregabalin, originally developed for epilepsy, and topical treatments like capsaicin cream for symptom relief.

NYU Langone

NYU Langone Health in New York is an esteemed institution with a dedicated Peripheral Neuropathy Center. Their team consists of specialists in various fields, including neurologists, radiologists, and rheumatologists, ensuring comprehensive care. NYU Langone offers easily accessible and advanced diagnostic testing, along with personalized, cutting-edge treatment plans.

Mount Sinai Hospital

Mount Sinai Hospital in New York, recognized as a top facility for neurology and neurosurgery by U.S. News & World Report, offers excellent care for peripheral neuropathy patients. Their team of neurologists and neurosurgeons work closely with specialists from other relevant fields to provide comprehensive treatment plans. Mount Sinai's personalized approach and interdisciplinary care ensures a high level of expertise and access to top-quality resources for patients.

Northwestern Medicine

Northwestern Medicine in Chicago provides top-level care for patients with peripheral neuropathy, with their neurology and neurosurgery departments being highly ranked by U.S. News & World Report. Their multidisciplinary team of specialists collaborates to create highly individualized treatment plans. Northwestern Medicine offers advanced diagnostic services, innovative therapies, and extensive experience in treating various types of peripheral neuropathy.

In summary, Mayo Clinic, NYU Langone, Mount Sinai Hospital, and Northwestern Medicine are among the best hospitals to treat peripheral neuropathy. These institutions combine expertise, access to advanced resources, and multidisciplinary approaches to provide exceptional care for patients experiencing peripheral neuropathy.

Treatment Options


There are several medications available to treat peripheral neuropathy. Some common ones include:

  • Gabapentin (Gralise, Neurontin, Horizant): Originally developed to treat epilepsy, it may relieve nerve pain. Side effects can include drowsiness and dizziness.
  • Pregabalin (Lyrica): Another anti-epileptic drug that can help with nerve pain, although it was the least effective in one study with only 15% of subjects reporting significant improvement.
  • Nortriptyline: This medication was the most effective treatment in the same study, with 25% of subjects reporting their discomfort improved by at least 50%. However, it also had the highest rate of side effects.
  • Topical treatments: Capsaicin cream, containing a substance found in hot peppers, can cause modest improvements in peripheral neuropathy symptoms.

Physical Therapy

Physical therapy is often an essential part of the treatment plan for peripheral neuropathy. It may include:

  • Stretching exercises: to improve flexibility and maintain muscle strength
  • Balance training: to help counteract the effects of nerve damage on balance and coordination
  • Aerobic exercises: to enhance overall fitness and promote better blood flow to the affected nerves

Pain Management

Various pain management techniques may be utilized to help individuals cope with neuropathic pain. Some options are:

  • Over-the-counter pain relievers: Nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen may help relieve mild to moderate pain.
  • Prescription painkillers: For more severe pain, a physician may prescribe stronger pain medications.
  • Antidepressants: Some types, such as tricyclic antidepressants and selective serotonin-norepinephrine reuptake inhibitors, may be useful in managing neuropathic pain.

Surgical Care

In some cases, peripheral nerve surgery might be necessary for patients with nerve compression, neurofibromatosis, or those who require surgical removal of a tumor affecting the nerves. Surgical care options include:

  • Peripheral nerve decompression: This surgical procedure can alleviate pressure on the nerves by removing surrounding structures or releasing tightness in the nerve's protective covering.
  • Tumor excision: When a nerve tumor is causing neuropathy, it may be necessary to surgically remove the tumor to relieve compression on the nerves.
  • Nerve repair: In cases of traumatic nerve injury, nerves may need to be surgically repaired or reconnected.

Each of these treatment options can play an important role in managing peripheral neuropathy. A specialist in neurology and pain management will help determine the most suitable approach based on the specific type of neuropathy, affected nerves, and the patient's overall health.

Specialist Care and Coordinated Teams

Peripheral neuropathy requires specialized care by dedicated and coordinated medical teams to ensure the best possible outcome for patients.


  • UCLA Health's Peripheral Nerve Program is known for its state-of-the-art care, provided by specialists who research and treat all types of peripheral nerve disorders [source].
  • Mayo Clinic specialists treat more than 16,400 people with peripheral neuropathy each year, boasting high-ranking hospitals for neurology and neurosurgery [source].


  • Neurosurgeons at UCLA Health's Peripheral Nerve Program are experienced in performing peripheral nerve repair and restoration, making it one of the highest-volume centers in California for this service [source].
  • Johns Hopkins Peripheral Nerve Center offers its patients expert neurological and medical care for peripheral neuropathies, and connects them with the best treatment approaches by partnering with other centers across Johns Hopkins [source].

Pain Specialists

  • The Pain Management Center at UCLA Health offers a comprehensive range of services for patients with peripheral neuropathy, including pain specialists who work collaboratively with neurologists and neurosurgeons [source].
  • The Pain Rehabilitation Center at Mayo Clinic provides pain specialists who offer support and care for peripheral neuropathy patients through evidence-based education, therapy, and skills training designed to reduce pain and enhance function [source].

These hospitals provide specialized care by neurologists, neurosurgeons, and pain specialists who collaborate and work together as coordinated teams to deliver the best possible care and treatment for patients with peripheral neuropathy.

Research and Clinical Trials

Johns Hopkins Neurology is at the forefront of peripheral neuropathy research. Their Peripheral Nerve Center focuses on several topics, including mechanisms of inefficient nerve regeneration in humans and ways to promote faster and more complete nerve generation using animal models and novel biomaterials research. They also investigate nerve degeneration mechanisms caused by chemotherapy drugs and diabetes1.

Mayo Clinic's research in peripheral neuropathy is well-regarded as well. They are involved in conducting clinical trials for peripheral neuropathy treatment, which is a nerve problem causing pain, numbness, tingling, swelling, and muscle weakness in different parts of the body2. Their studies have explored potential treatments such as topical cryotherapy, which may help relieve pain from peripheral neuropathy or acute pain syndrome caused by chemotherapy2.

The following are some key institutions involved in peripheral neuropathy research and clinical trials:

  • Johns Hopkins Neurology1
  • Mayo Clinic2
  • National Institute of Neurological Disorders3
  • Duke Health4

An important aspect of these institutions' research is to understand peripheral neuropathy in terms of the many conditions that involve damage to the peripheral nervous system. This complex network sends signals between the central nervous system and all other parts of the body, with peripheral nerves transmitting various sensory information to the central nervous system3.

In addition to offering cutting-edge treatments, these institutions provide access to research studies and clinical trials as part of a comprehensive approach to peripheral neuropathy care5. For example, Mayo Clinic is recognized among the Best Hospitals for neurology and neurosurgery, and is ranked highly performing for cancer by U.S. News & World Report5.

Overall, these institutions are leading the way in both research and clinical trials to better understand and treat peripheral neuropathy and to improve the lives of those affected.

Insurance and Quality Care

Acceptance of Insurance

When seeking treatment for peripheral neuropathy, it is essential to consider whether the hospital accepts your insurance. Many top hospitals, such as Johns Hopkins and Mayo Clinic, work with a variety of insurance providers to ensure patients can access quality care. Before scheduling an appointment or consultation, be sure to verify that your insurance plan is accepted. This information can often be found on the hospital's website or by contacting their financial services department.

Focus on Quality

In addition to insurance acceptance, focusing on the quality of care is crucial when choosing a hospital for peripheral neuropathy treatment. Top hospitals, such as those mentioned in the U.S. News & World Report rankings, often have:

  • Experienced specialists with expertise in treating peripheral neuropathy and related conditions
  • Access to advanced diagnostic tools and treatment options
  • Collaborative and multidisciplinary approaches to care

Quality care is especially important in the context of stroke, as peripheral neuropathy patients may be at a higher risk due to various factors, including:

  • Complications arising from diabetes, which may contribute to both neuropathy and stroke
  • A sedentary lifestyle and limited mobility, leading to increased risk of blood clots
  • Potential side effects of certain medications used to treat neuropathy

By prioritizing insurance acceptance and the quality of care, patients with peripheral neuropathy can find the best hospital for their specific needs and ensure they receive the appropriate treatment and support throughout their medical journey.

Alternative Therapies


Meditation is a mind and body practice that can help people with peripheral neuropathy manage their symptoms. By focusing on the interactions among the brain, mind, body, and behavior, meditation may affect physical functioning and promote health1. Some techniques that can be beneficial for peripheral neuropathy patients include deep breathing exercises, progressive relaxation, and mindfulness meditation. These practices can aid in reducing stress, improving psychological well-being, and potentially alleviating pain associated with peripheral neuropathy1.


Another alternative therapy for peripheral neuropathy is acupuncture. This traditional Chinese medicine technique involves the insertion of thin needles at specific points on the body to stimulate the peripheral nervous system. Research has shown that acupuncture can be an effective treatment for various types of peripheral neuropathy, providing relief from pain and improving nerve function2. It is essential for patients to find a licensed and experienced acupuncturist to ensure safe and effective treatment. Contractual agreements between hospitals and acupuncturists can facilitate the integration of acupuncture into a comprehensive peripheral neuropathy treatment plan.

It is important to note that alternative therapies may not work for everyone, and their effectiveness may vary based on individual factors such as the type and severity of peripheral neuropathy. Patients should consult their healthcare providers before starting any alternative therapies and integrate these practices with traditional medical treatments to achieve the best possible outcomes.


  1. Johns Hopkins Neurology Peripheral Nerve Center 2 3 4

  2. Mayo Clinic Peripheral Neuropathy Clinical Trials 2 3 4

  3. National Institute of Neurological Disorders 2

  4. Duke Health Neuropathy

  5. Mayo Clinic Peripheral Neuropathy Care 2